Camelia Shiseido

Defend Beauty

Defend beauty. Give your skin the strength it needs.
The skin's defence system is fundamental for healthy-looking skin.

Beauty is a feeling that is shared among all people, no matter their culture. It is a positive force that inspires us.




What is Ultimune?

Shiseido has been researching skin defence for over 20 years.

Ultimune is a product that embodies Shiseido skincare. It strengthens the skin’s natural powers of defence, enabling it to construct its own beauty.
It enhances the benefits of skincare products that follow.
Smooth, supple, and with fewer fine lines - skin radiates with health.

What is skin defence?

Just like your body, your skin has its own defence system.

Want to know more? Learn More

The skin is a dynamic organ that contains different cells that are activated when the tissue is under attack by invading external aggressors (such as pathogens and pollution). As your skin is the first line of defence against irritants like time, sun exposure and stress, the condition of your skin’s defensive system is critical for self-repair.

Langerhans cells (present in the epidermis) play a crucial role in skin’s protection, triggering a defence system against stressors in order to achieve skin's highest beauty potential. When the function of Langerhans cells declines due to UV rays, dryness and emotional stress, it can cause skin concerns such as a loss of firmness, wrinkles and dark spots may appear.

After more than 20 years of research, Shiseido has discovered the effect the skin’s defensive system has on the health of the skin and created a complex that successfully supports Langerhans cells.*

*in vitro test




Exclusively developed ingredients to defend beauty.

Ultimune ComplexTMcomprising of superior, originally-developed and naturally occurring ingredients, Ultimune ComplexTM nourishes and shields your skin, and defends against the harmful effects of external hazards.

Defends your skin against oxidation and harmful substances with the power of plants.

Ginko Biloba, Perilla (Eastern herb), Wild Thyme (Western herb) ‒ an anti-oxidant, among other effects.

Fragrance experience.

Rose, Lotus – a relaxing influence.

The Impact of Ultimune


Your skin texture is smoother and more supple.*

“This is the first time I’ve used a skincare product and noticed visible results. I like how easily it is to apply and how silky it feels. I have definitely seen the texture and plumpness of my skin improve after use.”

In 1 Weekarrow

Your skin tone is clearer and more radiant.*

“My skin has obviously responded to using this product. From daily application, I’ve noticed my cheeks look less sullen when I wake up, and my skin tone is definitely brighter.”

In 4 Weeks

Your skin contour appears firmer and more resilient.*
Want to continue using this product.*
Feel skin become strong.*
Want to add this product to my current facial skincare routine.*

*Tested on over 220 women, self-evaluation.

The Benefits of Combined Use

Combine the power of Ultimune with our Bio Performance and double the protection for your skin. Enjoy the benefits morning and night for beautiful, visible results.


After 4 weeks using Bio Performance and Ultimune together.

the hydration for your skin*
Advanced Super Revitalizing Cream
*Instrumental test on 30 women - 4 weeks - Ultimune + cream vs cream

After 4 weeks using Bio Performance and Ultimune together.

women consider their skin smoother**
Advanced Super Restoring Cream
**Auto-evaluation test on 219 women - 4 weeks - Ultimune + cream

After using Ultimune with a multi-functional serum for 2 weeks:

Skin appears more radiant and youthful.***

Glow Revival Serum
felt they were more powerful when used together.***
felt the multi-functional serum’s repairing effects had been enhanced.***
***The test items used were Ultimune Power Infusing Concentrate and Bio-Performance Glow Revival Serum, as Shiseido’s standard multi-functional serum, for a combined usage test. Test on 110 women, self-evaluation.

Ultimune as a Daily Ritual


Apply twice daily, morning and evening, after cleansing and balancing skin.


Press the pump twice to dispense serum into the palm of your hand.


When used with other serums, apply Ultimune first.

For the Eyes: Ultimune Eye

The area around the eye contains the most delicate skin on the entire face. It requires special care.

Ultimune Power Infusing Eye Concentrate

Shiseido developed ImuMoisture ExtractTMan ingredient unique to Ultimune Eye that protects the delicate skin around eye for a fully nourished eye area.

Ultimune Eye